GeneRanger
GeneRanger is a web-server application that provides access to processed data about the expression of human genes and proteins across human cell types, tissues, and cell lines from several atlases.
Identify targets with:
TargetRanger
GeneRanger
Identify targets with:
TargetRanger
Transcriptomics
ARCHS4, developed by the Ma’ayan Lab, contains over 1 million samples of uniformly processed RNA-seq data from the Gene Expression Omnibus (GEO). The samples were aligned using kallisto with an efficient parallelized cloud workflow. website | citation
GTEx transcriptomics provides bulk RNA-seq data for 54 human tissues collected from postmortem donors. The GTEx database was designed to study the relationship between genetic variation and gene expression across multiple human tissues. website | citation
Tabula Sapiens is a gene expression atlas created from single cell RNA-seq data collected from multiple tissues of 16 postmortem donors. The processed data contains average expression of each human gene in 486 cell types. website | citation
The Cancer Cell Line Encyclopedia (CCLE) transcriptomics dataset contains gene expression data collected with RNA-seq from over 1000 human pan-cancer cell lines. website | citation
Proteomics
The Human Proteome Map (HPM) contains data from LC-MS/MS proteomics profiling protein expression in 30 human tissues collected from 17 adult postmortem donors. website | citation
The Human Protein Atlas (HPA) contains protein expression data from 44 normal human tissues derived from antibody-based protein profiling using immunohistochemistry. website | citation
The GTEx proteomics dataset has relative protein levels for more than 12,000 proteins across 32 normal human tissues. The data was collected using tandem mass tag (TMT) proteomics to profile tissues collected from 14 postmortem donors. website | citation
The Cancer Cell Line Encyclopedia (CCLE) proteomics dataset contains protein expression in 375 pan-cancer cell lines. Data was collected by quantitative multiplex mass spectrometry proteomics. website | citation
A2M
Short description (from NCBI's Gene Database): The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
Gene pages on other sites:
ARCHS4: ARCHS4, developed by the Ma’ayan Lab, contains over 1 million samples of uniformly processed RNA-seq data from the Gene Expression Omnibus (GEO). The samples were aligned using kallisto with an efficient parallelized cloud workflow. website | citation